Malaria vaccine shows early promise

August 8, 2013
By

Malaria parasiteLiving but weakened forms of the parasites were used in the new vaccine

A malaria vaccine has shown promising results in early stage clinical trials, according to researchers.

Researchers found the vaccine, which is being developed in the US, protected 12 out of 15 patients from the disease, when given in high doses.

The method is unusual because it involves injecting live but weakened malaria-causing parasites directly into patients to trigger immunity.

The research is published in the journal Science.

Lead author Dr Robert Seder, from the Vaccine Research Center at the National Institutes of Health, in Maryland, said: “We were excited and thrilled by the result, but it is important that we repeat it, extend it and do it in larger numbers.”

Many bites

It has been known for several decades that exposure to mosquitoes treated with radiation can protect against malaria.

However, studies have shown that it takes more than 1,000 bites from the insects over time to build up a high level of immunity, making it an impractical method of widespread protection.

Instead, a US biotech company called Sanaria has taken lab-grown mosquitoes, irradiated them and then extracted the malaria-causing parasite (Plasmodium falciparum), all under the sterile conditions.

Continue reading the main story

Start Quote

They are clearly very early stage trials in small numbers of volunteers, but without question we are extremely encouraged by the results”

End Quote
Dr Ashley Birkett
Path Malaria Vaccine Initiative

These living but weakened parasites are then counted and placed in vials, where they can then be injected directly into a patient’s bloodstream. This vaccine candidate is called PfSPZ.

To carry out the Phase-1 clinical trial, the researchers looked at a group of 57 volunteers, none of whom had had malaria before.

Of these, 40 received different doses of the vaccine, while 17 did not. They were then all exposed to the malaria-carrying mosquitoes.

The researchers found that for the participants not given any vaccine, and those given low doses, almost all became infected with malaria.

However for the small group given the highest dosage, only three of the 15 patients became infected after exposure to malaria.

Dr Robert Seder said: “Based on the history, we knew dose was important because you needed 1,000 mosquito bites to get protection – this validates that.

“It allows us in future studies to increase the dose and alter the schedule of the vaccine to further optimise it. The next critical questions will be whether the vaccine is durable over a long period of time and can the vaccine protect against other strains of malaria.”

Anopheles mosquito Malaria kills about 600,000 people each year and infects more than 200 million

He added that the fact that the vaccine had to be injected into the bloodstream rather than into or under the skin made delivery more difficult.

Commenting on the research, Dr Ashley Birkett, from the Path Malaria Vaccine Initiative, said: “They are clearly very early stage trials in small numbers of volunteers, but without question we are extremely encouraged by the results.”

He added that most current vaccine candidates targeted parts of the P. falciparum parasite rather than the whole organism.

“This approach induces a broad response against a lot of different targets on the parasite,” he said.

There are currently about 20 malaria vaccine candidates in clinical trials.

The most advanced is called RTS,S/AS01, which has been developed by the pharmaceutical company GlaxoSmithKline, and is in a Phase-3 clinical trial involving 15,000 children in Africa.

According to the latest figures from the World Health Organization, there were an estimated 219 million cases of malaria in 2010 and an estimated 660,000 deaths.

Article source: http://www.bbc.co.uk/news/health-23607612#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa The feed :

Tags:

Sponsored By:

The Deeter Group

Deeter Electronics Ltd. | Deeter Electronics Inc | Deeter Group Asia | Deeter Group Germany | Deeter Group Corporate

Head & Registered Office:
Deeter Electronics Ltd.
Deeter House,
Valley Road,
Hughenden Valley,
Bucks. HP14 4LW

Tel: +44 (0) 1494 566 046
Fax: +44 (0) 1494 563 961
E-mail: [email protected]


The Deeter Group with products ranging from: , , , continuous , 4-20mA , , , , , , , a , wireless sensor and much more.

If you want a standard or a custom level switch, float switch, level sensor, or wireless sensor, contact us via email [email protected] or call us now on 01494 566 046.

Company Name: The Deeter Group

Location: Hughenden Valley, UK

Deeter Electronics USA
Deeter Electronics USA
Wireless sensor system | Radio telemetry | Level switches | Level sensors | Liquid level sensor | Float switches | Controllers & indicators | Industrial weighing equipment | Electronic circuit design & manufacture | Software design | Reed relays | Ultrasonic level flow sludge & proximity sensors | Proximity sensors & switches | Reed switches | Litz wire | Wago Terminals | Mechanical & magnetic floats | Boiler control |

Deeter Electronics UK
Wireless sensor system | Radio telemetry | Level switches | Level sensors | Liquid level sensor | Float switches | Controllers & indicators | Industrial weighing equipment | Electronic circuit design & manufacture | Software design | Reed relays | Ultrasonic level flow sludge & proximity sensors | Proximity sensors & switches | Reed switches | Litz wire | Wago Terminals | Mechanical & magnetic floats | Boiler control |

Deeter Electronics Europe
Wireless sensor system | Radio telemetry | Level switches | Level sensors | Liquid level sensor | Float switches | Controllers & indicators | Industrial weighing equipment | Electronic circuit design & manufacture | Software design | Ultrasonic level flow sludge & proximity sensors | Proximity sensors & switches | Reed switches | Litz wire | Wago Terminals | Mechanical & magnetic floats | Boiler control |

Sensor Magazine Websites
Explosion Proof Sensors UK | Explosion Proof Sensors | Water Level Measurement | Liquid Level Sensing | Liquid Level Measurement | Liquid Level Sensors UK | Liquid Level Sensors Europe | Wireless Sensors | Sensor Magazine | Industrial Sensors



Water use